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To find antibiotics of other groups except macrolidelincosamide group that can induce resistance in B. licheniformis EMR-1 which has an inducible resistance to macrolide-lincosamide antibiotics, nystatin, pimaricin, trichomycin and amphotericin B of the polyenes, mikamycin and rifampicin were examined in this study. the subinhibitory concentration(20 mcg/㎖) of penicillin V was added so that polyene antibiotics may act in the strain. All of these antibiotics except pimaricin and rifampicin had resistance-inducing activities in the strain to lincosamide antibiotics, but not to macrolide antibiotics. The subinhibitory concentrations of chloramphenicol, when added to culture broth prior the induction, interfered with its induction by erythromycin. This fact indicates, therefore, that the inducible resistance probably involved the synthesis of new protein.
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